Toshinori Fujie (Post-Doc)

Biography

Toshinori Fujie received his M.S. degree in polymer chemistry from the toshinorifujie250x300Department of Applied Chemistry in Graduate School of Advanced Science and Engineering of Waseda University (Tokyo, Japan) in March 2007 in the work of protein based nanoparticles for the construction of platelet substitutes. In March 2009, he skipped one year of his PhD course in Waseda University, and obtained his PhD degree (Engineering) from the Department of Life Science and Medical Bioscience in Graduate School of Advanced Science and Engineering of Waseda University with the doctorial thesis of “Construction of Biomacromolecular Nanosheets and Their Biomedical Application as a Wound Dressing Material”. During PhD course, he joined the Biomolecular Assembly Group at Waseda University, under the supervision of Prof. S. Takeoka with the external advisors of Assoc. Prof. Arianna Menciassi (Scuola Superiore Sant’Anna) and Prof. Rigoberto Advincula (University of Houston). His research interests were involved in biomaterials science through molecular assembly and polymer chemistry. In particular, he devoted much of his research efforts towards construction of freestanding polymeric ultra-thin structures (nanosheets) utilizing layer-by-layer assembly of biomacromolecules, and evaluation of them with the nano/micro-mechanical tests and mechano-biological approaches. Along with the PhD work, he attended the various collaborative researches including international works. In particular, he developed the biomedical application of nanosheets as a wound dressing materials with the group of National Defense Medical College (Saitama, Japan). In 2008, he also spent one month in University of Houston under the supervision of Prof. R. Advincula as a visiting researcher. He worked on a stimuli-responsive interface and constructed a polymer brushed nano-structure using atom transfer radical polymerization. From 2008, he started the international collaborative work with Prof. Paolo Dario’s group of Scuola Superiore Sant’Anna in the development of remote-controllable nanosheets for the endoscopic surgery. In 2009, he joined the faculty of Science and Engineering of Waseda University as a research associate and continued the collaborative researches. In April 2010, he moved his position to the European Biomedical Science Institute (EBSI), Organization for European Studies of Waseda University as a visiting researcher. In July 2010, he joined the IIT accepting a Post-Doc Junior position at Center for Micro-BioRobotics IIT@SSSA in Pontedera (PI). He is currently a member of American Chemical Society, The Chemical Society of Japan and The Society of Polymer Science, Japan.

He is currently working on Smart Materials Platform in the team leaded by Virgilio Mattoli. His research interests are directed to the development of remote-controallable nanosheets for the endoscopic surgery and biohybrid ultra-thin actuators with consolidated nanostructures. His work is mainly focused on the design of hierarchical nanostructure composed of electromagnetic materials and biological species utilizing self-assembly as well as investigation of cell/material interfacial agglutination for the development of smart materials..

 

Publications

International Journals

  1. Niwa, D., Fujie, T., Lang, T., Goda, N., Takeoka, S. "Heterofunctional nanosheet controlling cell adhesion properties by collagen coating". J. Biomater. Appl., in press (2011). DOI: 10.1177/0885328210394470
  2. Fujie, T., Furutate, S., Niwa, D., Takeoka, S. "A nano-fibrous assembly of collagen / hyaluronic acid for controlling cell-adhesive properties". Soft Matter, 6, 4672-4676 (2010).
  3. Ricotti, L., Taccola, S., Pensabene, V., Mattoli, V., Fujie, T., Takeoka, S., Menciassi, A., Dario, P. "Adhesion and proliferation of skeletal muscle cells on single layer poly(lactic acid) ultra-thin films". Biomed. Microdevices, 12 (5), 809-819 (2010).
  4. Fujie, T., Saito, A., Kinoshita, M., Miyazaki, H., Ohtsubo, S., Saitoh, D., Takeoka, S. "Dual therapeutic action of antibiotic-loaded nanosheets for the treatment of gastrointestinal tissue defects". Biomaterials, 31, 6269-6278 (2010).
  5. Matsutani, N., Fujie, T., Ozeki, Y., Takeoka, S. "Basic consideration on tissue adhesion and sealing of ultra-thin nanobiomaterial in visceral pleural defect repair". JACSURG, 1, 2-7 (2010).
  6. Fujie, T., Park, J-Y., Murata, A., Estillore, N. C., Tria, M. C. R., Takeoka, S., Advincula, R. C. "Hydrodynamic transformation of a free-standing polymer nanosheet induced by a thermoresponsive surface", ACS Appl. Mater. Interfaces, 1, 1404-1413 (2009).
  7. Okamura, Y., Takeoka, S., Eto, K., Maekawa, I., Fujie, T., Maruyama, H., Ikeda, Y., Handa, M. "Development of fibrinogen g-chain peptide-coated, adenosine 5’-diphosphate-encapsulated liposomes as a synthetic platelet substitute". J. Thromb. Haemost., 7, 470-477 (2009).
  8. Fujie, T., Kinosita, M., Shono, S., Saito, A., Okamura, Y., Saitoh, D., Takeoka, S. "Sealing effect of a polysaccharide nanosheet for murine cecal puncture". Surgery, 148, 48-58 (2010).
  9. Fujie, T., Matsutani, N., Kinoshita, M., Okamura, Y., Saito, A., Takeoka, S. "Adhesive, flexible and robust polysaccharide nanosheet integrated for tissue-defect repair". Adv. Funct. Mater., 19, 2560-2568 (2009).; “Fit to repair”, Nature Nanotech. (Research Highlights), 4, 472 (2009)
  10. Fujie, T., Okamura, Y., Takeoka, S. "Selective surface modification of free-standing polysaccharide nanosheet with micro/nano-particles utilizing structural color". Colloids and Surface A: Physicochemical and Engineering Aspects 334, 28-33 (2009).
  11. Takeoka, S., Okamura, Y., Fujie, T., Fukui, Y. "Development of biodegradable nanosheets as nano-adhesive plaster". Pure Appl. Chem., 80 (11), 2259-2271 (2008).
  12. Okamura, Y., Fujie, T., Nogawa, M., Maruyama, H., Handa, M., Ikeda, Y., Takeoka, S. "Hemostatic effects of polymerized albumin particles carrying fibrinogen g-chain dodecapeptide as platelet substitutes in severely thrombocytopenic rabbits". Transf. Med. 18, 158-166 (2008).
  13. Fujie, T., Okamura, Y., Takeoka, S. "Ubiquitous transference of free-standing polysaccharide nanosheet in the development of a nano-adhesive plaster". Adv. Mater. 19, 3549-3553 (2007).
  14. Okamura, Y., Fujie, T., Maruyama, H., Handa, M., Ikeda, Y., and Takeoka, S. "Prolonged hemostatic ability of poly(ethylene glycol)-modified polymerized albumin particles carrying fibrinogen g-chain dodecapeptide". Transfusion 47, 1254-1262 (2007).

 Communications at conferences

  1. Mattoli, V., Pensabene, V., Fujie, T., Taccola, S., Menciassi, A., Takeoka, S., Dario, P. Fabrication and characterization of ultra-thin magnetic films for biomedical applications. Procedia Chemistry (Proc. EuroSensors XXIII Conference 2009), 1(1), 28-31 (2009).
  2. Fujie, T., Matsutani, N., Kinoshtia, M., Okamura, Y., Saito, A., Takeoka, S. “Biomedical application of polysaccharide nanosheet for tissue-defect repair”, Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.), 50(2), 432-433 (2009).
  3. Pensabene, V., Fujie, T., Mattoli, V., Menciassi, A., Takeoka, S., Dario, P. “Magnetic nanosheet adhesion to mucosal tissue”, Proc. IEEE Nano, Genova, 1, 489-493 (2009).
  4. Takeoka, S., Fukui, Y., Fujie, T., Okamura, Y. Novel Polymeric Nanosheets for Gerontic Applications. Gerontechnology, 7, 220-224 (2008).
  5. Takeoka, S., Fujie, T., Okamura, Y. “Manipulation of free-standing polysaccharide nanosheets and their application on a nano-adhesive plaster”, Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.), 48(2), 976-977 (2007).
  6. Okamura, Y., Fujie, T., Handa, M., Ikeda, Y., Takeoka, S. “Hemostatic effects of polymerized albumin nano-particles carrying fibrinogen-g chain dodecapeptide as platelet substitutes”, Polym. Prep. (Am. Chem. Soc., Div. Polym. Chem.), 47(2), 854-855 (2006)

Patents

  1. “Thin film-like polymer structure and method for preparing the same” PCT/JP2007/071437, Shinji Takeoka, Yosuke Okamura, Toshinori Fujie, Saori Utsunomiya, Takahiro Goto.